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Senior Bioinformatics and Data Scientist . . For more details on my work and resume see : http : jhmarcus.com . Technologies :

Graduate Researcher . Ansu Satpathy Lab . I am a second year PhD candidate in the Genetics Department at Stanford . I develop both experimental and computational genomic methods to study immunological disorders , especially cancer . Bilingual in tech and biology , I want to bring cutting edge science to patients through biotech entrepreneurship . Let s chat vincentliu.info . Technologies :

Statistician . . . Technologies :

Scientist Molecular engineering . . Graduated PhD student in Biochemistry and Biotechnology . Motivated scientist , with expertise in the field of antibody engineering and discovery and infectious disease . Technologies :

biologics;engineering

Senior Scientist . . Field tested bioinformatics scientist driven by joyful wonder at the molecular mechanisms of life , guided by rigorous methodological training . Experienced with RNA Seq , cfDNA seq , DNA seq , mass spectrometry , ChIP Seq . Strong command of R , Perl , and C . Expertise in immuno oncology , predictive biomarkers , data visualization , network biology , chromatin , and gene regulation .. Technologies :

Research Fellow , ECIR Affiliate Computer Science and AI Laboratory , . . Specialties : Security : Threat and vulnerability analysis , Cyberontology mapping , Smart grid Security , Cybersecurity Policy : Nation state strategy Analysis Norms formation in Cyberspace , Artificial Intelligence Machine Learning , Knowledge Representation , Software Engineering Model Driven Architecture , Formal Methods , Semantic Interoperability in large scale data sharing , Bioinformatics Large scale data Integration in genomics and medical informatics .. Technologies :

Proleptic Lecturer in Animal Sensing and Biometrics . . I am a zoologist experimental psychologist whose research interests primarily concern computational approaches to applied vision and questions lying at the intersection of sensory biology , psychology , history and art . I am particularly passionate about how visual scenes can be understood using computer vision and what comparisons can be drawn with biological visual systems . Academic profile : https : camolab.com members talas CV : https : github.com laszlotalas cv . Technologies :

Scientist Radiopharmacy . Precirix is a clinical stage biotechnology company dedicated to improving the lives of cancer patients by developing novel targeted radiopharmaceuticals using camelid single domain antibody fragments . The company is advancing its lead product CAM H2 through a Phase I II clinical trial targeting HER2 positive tumors , while further progressing and broadening its oncology pipeline . Precirix technology platform allows for a theranostic approach , using the same molecule for patient selection imaging and therapy . At Precirix , I am part of the Chemistry , Manufacturing Control Radiochemistry team . . Professional in life sciences with a strong background in radiopharmaceutical research , recently graduated as a Doctor of Pharmaceutical Sciences from KU Leuven . In my research work , I contributed to the development of new diagnostics for cancer patients in the field of molecular imaging . . Technologies :

antibodies;developing;interaction

Scientist . Scientist with a commercial mindset . I am an ambitious and knowledge hungry bioscientist . I enjoy working in smaller teams , preferably interdisciplinary ones where I find myself being on the top of my science game . I am not afraid of hard work or elbow grease and I thoroughly enjoy learning new stuff . In 2009 , I obtained a Masters degree 1 year in Biomedicine from Lund University , Sweden . The research for my Masters thesis was conducted at University of California San Fransisco , and was focused on G Protein coupled Receptors GPCRs , one of the most prevalent types of drug targets . This is also when I got my first experience in advanced experimental methodology . In 2015 , I gained my Ph.D. diploma Molecular Pharmacology from Lund University , Sweden . The project was focused on the characterization of a specific GPCR . I gained a lot of experience in pharmacology , receptor signaling , intracellular signaling pathways , elucidation of mechanism of actions for pharmaceuticals and preclinical drug discovery methodology . After my Ph.D. , I was working as a postdoc at Boston University , MA , USA , characterizing a novel family of proteins termed non receptor GEFs . I learned a lot about structure biology , protein biochemistry and how to do good science using yeast and bacteria . In November 2017 , ReceptorPharma was founded by me and an entrepreneurial partner with the vision of becoming a leading drug discovery company focused on targeting disease associated orphan GPCRs coupled to neurodegenerative and other diseases . My scientific background has made me a competent in vitro pharmacologist with in depth knowledge of cell biology , biochemistry , molecular biology , drug discovery , neurobiology and more . As a Ph.D. , I know what it takes to successfully drive larger projects , how to meet crucial deadlines and quickly learn new scientific methodology . I am most definitely intrinsically curious when it comes to most things science . Knowledge is power . As an entrepreneur , for three years I have been following my passion for drug discovery while expanding my know how in business development . In addition to above mentioned interests and experiences , I have a secret passion for what I could call biofungal innovation a convergence of multiple different disciplines . Waste product management and refinement , innovative building materials from renewables , novel potential routes in drug discovery , creation of functional foods and more . Fungi , are just that extremely interesting and I am personally certain they will revolutionize many industries in the coming decades .. Technologies :

membrane proteins;interaction

Chief Research Officer . . I believe that the future of biology and medicine relies on advances in computational approaches . Data collection will become more automated and routine , paving the way for advanced analytics to add value by enabling better predictions of alternative design choices , but also suggesting which data should be collected to maximise return on investment . I have a keen interest in blending dynamical systems theory with machine learning . My recent work has included basic research into the adaptive immune system , exploring the potential for novel forms of computation using DNA instead of silicon , engineering emergent pattern formation in cellular systems using synthetic biology , and understanding trade offs in biopharmaceutical manufacturing of lentiviral vectors . Experience : I have 12 years experience working in industry based research Microsoft Research , have published over 40 peer reviewed papers and developed several open source software packages . For more details on this , please visit my website ndalchau.github.io .. Technologies :

Senior Research Scientist Sr . Manager Pharmaceutical Development . Research Associate II : 2005 2007 : Solutions R D group as exploratory project lead , solutions chemistry animal expertise . Research Associate III : 2007 2009 : Exploratory R D group , Project Lead , in vivo in vitro expert . Research Scienist I : 2009 2010 : Renal New Product Introduction Project Lead and Solutions CMC Technical Lead Corporate Technical Award . Research Scientist II : 2010 2011 : Renal Solutions Life Cycle Management lab management 5 direct reports . Research Scientist II Manager Pharmaceutical Development : 2011 2015 : Renal solutions product support New Product Development CMC , . lab management 18 direct reports . Job titles have been changed in accordance to recent Baxter job title allignment . Senior Research Scientist Sr . Manager Pharmaceutical Development : 2015 current : . Technical R D Lead for New Pharmaceutical Product Development CMC , . projects in . Renal Therapy Peritoneal Dialysis , Hemodialysis , CRRT , Parenteral Nutrition , Intravenous Solutions , etc . support of product on the market Sustaining Products . . Senior Research Scientist Technical R D Leader in New Product Pharmaceutical Development covering R D activities from concept to launch and post launch . Technical scientific expertise : . 1 . Vaccine development : antigen selection production , in vitro tests , infection vaccination in vivo studies . KULeuven Intervet : 2000 2005 : immunology molecular biology animal science microbiology . 2 . Parenteral Solutions Baxter : 2005 current : analytical formulation chemistry CMC early to late phase development design studies , stability studies , . regulatory strategy in vivo models tox efficiency clinical trials Patents Project R D Management . Experience in leading New Product Development projects through various phases : exploratory in vitro in vivo models , preclinical tox PK , clinical studies proof of concept , CMC solution development , submission , launch and commercial product support . Experience in people management : . 1 . Direct : . Prior : laboratory management : 18 direct reports . Prior : Tech Lead management : 3 direct reports . 2 . Indirect : . Prior : core team leader . Current : Tech R D project leader : cross functional teams per project . Specialties : . in vivo infection vaccination ; dialysis , tox in vitro cell culture , antibody binding . Analytical Bio analytical methods : chemistry HPLC , biochemistry enzymatic assays , immunology ELISA , molecular biology PCR , Sequencing . Protein production purification , blotting . CMC : Chemistry formulation ; stability studies . Project management : project leader exploratory development projects , Budget project planning , Regulatory strategy . Technical R D lead : early late phase development projects and Sustaining Product projects : technical team lead coordination , CMC , interaction with regulatory and manufacturing , different product categories : Renal Therapy Peritoneal Dialysis , CRRT , Hemodialysis , Parenteral Nutrition , Intravenous Solutions , etc . . Technologies :

antibodies;interaction;stability

Project Scientist . Analyzing imaging data from X ray diffraction single particle imaging for use in determination of protein structure Performing large scale data simulations and post processing using world class HPC resources such as Summit 1 supercomputer in world Funded as part of the Exascale Computing Project ECP to increase data analysis throughput 1000x by 2025 Developing Python code to further expand software packages for analyzing X ray diffraction images using NumPy , SciPy , Matplotlib , and Jupyter notebooks . . Scientist with a demonstrated history of working in Computational Biology and Software Programming . Strong skills in Mathematical Modeling , Python , Matlab , and C . Strong professional with a PhD in Computer Science from University of California , Santa Barbara . Skilled in shell scripting , Git , and R .. Technologies : Xray

Associate Scientist . . Experienced Science Research Specialist with a demonstrated history of working in molecular biology and bioinformatics research field . Skilled in Good Laboratory Practice GLP , PCR , NGS , Microsoft Word , English , Java , C , R , and Python .. Technologies :

Senior Scientist . . Stefan Oliver is a creative senior scientist and educator with a special interest in the membrane fusion mechanisms of viral pathogens . Stefan uses and develops multidisciplinary approaches to delineate the molecular functions that underpin the mechanics of herpesvirus fusion . Recently he has been focused on solving near atomic resolution structures of antibody bound glycoproteins using contemporary cryo EM technologies . One of his overarching goals is to understand the complex interplay of the herpesvirus fusion complex with cellular factors at the atomic level using state of the art structural biology tools . In addition to his dedication to lab based science , Stefan is involved in community outreach supporting scientists of the future . He participates as a judge for science competitions and also lectures to high school students about STEM . He is a strong advocate for the scientific method and seeks to get the best out of his mentees at all stages of their careers , guiding high school students and postdocs through their research projects . Stefan s educational background includes a B.Sc . in Immunology and a Ph.D. in Veterinary Virology . He has spent more than 25 years in academic and biotechnology research laboratories in fields spanning immunology , pharmaceuticals , infectious diseases and structural biology . Special interests outside of his primary field of research are evolution and motorcycles . Stefan was the recipient of an American Motorcycling Association AMA Service award for providing information related to COVID 19 .. Technologies : CryoEM

antibodies;structure

Medicinal Chemist . . Currently Director of Medicinal Chemistry at Boehringer Ingelheim with leadership role in chemistry outsourcing . Academically and practically strong medicinal chemist with wide experience of both exploratory and lead optimisation chemistry . I have delivered leads and candidates across a range of disease areas Oncology , GI , respiratory , psychiatry , neurology , cardiovascular , anti infectives and a range of protein target classes 7TM s , kinases and other enzymes and nuclear receptors . I have over 15 years of experience in the pharmaceutical industry and have managed large teams of experienced medicinal chemists . Specialties : Medicinal Chemistry , fragment based drug discovery , structure based drug design , synthetic chemistry , people management , project management , data analysis , HTS follow up , chemoinformatics , team and matrix leadership , outsourcing , computational methods , lead identification , lead optimisation , people skills , patents . Technologies :

membrane proteins;proteins;small molecules;interaction;screening;structure

Scientist . . Biotechnologist with over 5 years of experience in academic , contract research organization Fraunhofer Gesellschaft and industry Dr. Fooke Achterrath Laboratorien GmbH . Expert in the development of recombinant proteins for in vitro diagnostic recombinant allergens and biopharmaceuticals fusion proteins , vaccine candidates , antibodies and antibody formats . Extensive knowledge in protein and antibody engineering , protein expression as well as protein characterization . Proven track record in recombinant proteins , antibody engineering , vaccine development and downstream processing DSP of different protein types . Current focus on the development of innovative downstream processing DSP strategies , implementation of design of experiments DoE approaches to accelerate process development . Development of antibodies or antibody formats for immunoassays , in vitro diagnostic or therapy . Experienced in project management . Ability to conceive project proposals and transfer R D activities to cGMP process development , I am known to efficiently identify , improve and realize complex work processes and deliver results within timelines and budget .. Technologies :

antibodies;biologics;characterization;engineering;expression

Bioinformatician . Long term data science work on multiple biomedical projects 60 datasets for 20 different projects . Machine learning and statistics on terabyte scale datasets . Involved in entire recruitment pipeline , from designing skills test , to selecting candidates for interviews , interviewing , and final recruitment decisions . Teaching machine learning to PhD students and Postdocs at University . Mentoring junior colleagues and coached intern with weekly 1 on 1 meetings to contribute to open source software and scientific publication . Intern is now joining the group as a full time employee . Co authoring multiple scientific publications https : scholar.google.com citations hl en user Q iGdrkAAAAJ view op list works sortby pubdate . My extensive experience with large scale biomedical data science has driven my enthusiasm for effective and explainable machine learning for real world problems , enabling data driven decision making . I invest in team building from recruitment through integration : I have developed skills tests for recruitment and interviewed candidates , as well as having provided long term supervision and mentoring of junior group members . I am also passionate about education and pedagogy for machine learning and related quantitative skills . During my time in academia I have enjoyed a number of highly inter disciplinary collaborations which resulted in several peer reviewed scientific publications https : scholar.google.com citations hl en user Q iGdrkAAAAJ view op list works sortby pubdate . Furthermore , I am the author and maintainer of the ClustAssess R package https : cran.r project.org package ClustAssess , which enables high resolution evaluation of clustering results .. Technologies :

Scientist . Develops custom software infrastructure for emergent high throughput laboratory R D processes DNA assembly , microbial strain engineering , NGS . Interfaces with software engineers to establish requirements for Zymergen 's Exploration Discovery Department . Supports experimental design , data management , and computational analysis for genetic engineering R D efforts . Developed multidisciplinary methods lab computational to inform product ideation and establish proof of concept for future product pipeline . Developed computational pipelines for de novo transcriptomic elucidation of commercially relevant novel genes from poorly characterized organisms . Collaborated with analytical chemists to develop screening assay for a novel compound identified by computational work . Participated in client scoping with Business Development to identify the key biological technical risks in new commercial partnerships . Served as laboratory co manager during large expansion of a R D automation laboratory . . Currently leveraging over a decade of wet lab experience as a full time Python developer supporting bioinformatics and R D. Expert in computational approaches that inform experimental design and analysis . Excels at big data manipulation , including computational analysis of sequencing data HTS NGS and genomic datasets . Extensive knowledge of cell biology , including genetics , genomics , and biochemistry . Thorough understanding of molecular genetic and biochemical laboratory techniques . Motivated by dynamic and challenging learning environments . Driven by the intersection of basic research , commercial application , and science entrepreneurship .. Technologies :

Senior Scientist . Protein Production . My research interests include development of enzymes proteins and carbohydrates for health related and industrial applications . I have experience in heterologous protein expression : in Escherichia coli , methylotrophic yeast Pichia pastoris ; protein purification : gel filtration , ion exchange , affinity chromatography KTA , ultrafiltration Millipore ; enzymology : kinetic analysis , stability , binding interaction ; and molecular biology : protein engineering , cDNA cloning . Characterisation of carbohydrate active enzymes for industrial application as well as purification and analysis of carbohydrates and proteins using various techniques : HPAEC PAD , HPLC Dionex , MALDI TOF MS Bruker Daltonics , DSC MicroCal , SPR Biacore and TLC are the research experiences up to date . Specialties : Enzyme Protein production , purification and characterisation Carbohydrate active enzymes Enzymatic synthesis of carbohydrate . Technologies : ITC;DSC;SPR

enzymes;proteins;characterization;engineering;expression;interaction;structure

Manager , Bioinformatics Tissue Oncology . Team leader responsible for optimization of Guardant s assays by implementing algorithms to improve calling models and pioneer novel biomarker development . Responsibilities : Provide leadership and mentorship to the algorithm development team As an individual contributor , build and improve statistical models to analyze genomic and functional genomics data generated by Guardant 's proprietary assay Guide or formulate feasibility analyses , including statistical modeling and machine learning methods Analyze large volumes of NGS data and work in conjunction with assay development scientists to plan experiments and establish optimal assay conditions Keep up with the state of the art in the field and suggest novel methods , markers , and approaches to therapeutic selection Keep detailed , reproducible documentation of analysis , methods , and version controlled code Present results of your work to the broader organization . Highly accomplished principal bioinformatics scientist focused on the identification of new targets and biomarkers in cancer and age related diseases . Analyzed and examined complex data and evaluated the statistical methods and procedures used to obtain data in order to ensure validity , applicability , efficiency , and accuracy . Excels at Next Generation Sequencing NGS data analysis and the assessment of transcriptome profiling using open source software . Experience in developing and implementing pipelines for the processing of high throughput sequencing data . Created reusable macros and developed R Programs for Data Cleaning , Validation and Analysis and Report generation . Analyzed and examined complex data and evaluated the statistical methods and procedures used to obtain data in order to ensure validity , applicability , efficiency , and accuracy . Familiar with repositories of analysis tools and genomic data sets such as Bioconductor , Genomatix , UCSC Genome Browser , cbioportal , TCGA and NCBI databases . Proficient in working in a UNIX LINUX environment . 4 years of project management experience across product value chain . Experiences include strategy formation implementation , project management , market research , customer etc . Strong analytical skills and proven record in using data to derive strategy insights . Patents Galectin 3 nsSNPs : Markers for cancer . Raz , A. , Balan , V. , Nangia Makker , P. Wayne State University USSN 12 365,588 Removal of senescence associated macrophages . A. Gudkov , A. Polinsky , V. Balan , O. Chernova , B. M. Hall , P. G. Komarov , D. N. Kazyulkin , Everon Biosciences , United States patent application US 16 096,601 . 2020 Apr 23 . US2017 029372 , WO2017189553A1 Gene Discovery Isolation and identification of the new gene D NAAM . In : Balan V et al . 2008 Lifespan extension and neuronal cell protection by Drosophila nicotinamidase . JBC 238 41 : p. 27810 27819 . Technologies :

Senior Research Scientist . Responsible for assay development and validation to support lead optimization efforts and mechanistic evaluation of lead molecules Responsible for key cell line generation and paired isogenic CRISPR knockout cell line generation used to support pipeline program campaign . Developed and optimized both MSD UPLEX and one step luciferase reporter platforms for routine use in compound screening . These enhanced assays greatly improved throughput efficiency in assessing on target activity and driving SAR efforts around selectivity . . Passionate and highly versatile senior biologist with 14 years preclinical in vivo pharmacology and molecular biology experience in small molecule drug discovery research . Very strong interpersonal , organizational , communication skills resulting in successful and productive multi matrix relationships . Proven track record in continuous development and advancement of skill set . Excels in both a team setting and independently to drive performance and is flexible in adapting to changes . Open to seeking a position that pairs scientific experience , responsibility , and skill set in drug discovery with additional opportunities in clinical science and development .. Technologies :

small molecules;screening

Development Scientist . Process optimization to increase quality and efficiency standards of in vitro diagnostic and bioanalytical assays for virology and screening blood products . Knowledge with modern instruments such as Cobas 6800 8800 . . PCR and RT PCR assays for IVD . Protein extraction and purification . Experience in HPLC . Chromatography . Antibody screening ELISA . Flow Cytometry . MACS sorting . DNA RNA extraction and purification . Experience with mammalian cell culture . . Technologies :

Postdoctoral Researcher . Wrote the VISFD 3D image processing template library C 11 for detecting features in Cryo EM images solving the 3D insidedness computer vision problem . Compared these features with coarse grained simulations of viruses and bacteria . This is a continuing collaboration with my previous lab . . I write general software to simulate the machinery of the cell and active matter . I also develop software to interpret 3D data from microscopy experiments which I compare with my simulations . Publicly available programs I have written include MOLTEMPLATE moltemplate.org , MINRMS structural bioinformatics , VISFD volumetric image processing , and the molecular cellular automata extensions for the LAMMPS molecular dynamics simulation engine lammps.sandia.gov .. Technologies : CryoEM

Head of Unit Simulation and Learning Technology . . Mindset : To make the impossible possible By using an open and innovative mindset and with a basic believe in skilled people values it s easy to create , mature and facilitate new ideas . Experienced and profound leader and life science manager : 3 years in the Danish Healthcare System , 15 years in Diabetes Research in the Pharmaceutical Industry and 2 years in Biotech . MSc in Biotechnology Part of the Human Genome Project , PhD within G protein coupled receptor pharmacology . 10 years within leadership , people management , innovation and strategy including : change management , communication strategies , organizational structuring , innovation mindset , new idea generation processes and educational environments Lot of research and development experiences from academia , industry and public institutions I am fascinated on how leadership and good communication can engage and develop people , teams and organizations into new directions . My motivation is clearly to make synergy between people , to find new and better solutions and to make a difference for people and society .. Technologies :

Senior Scientist . . Self motivated scientist with experience in elucidating late phase Hematology and Oncology drug mechanism , helping to develop rational drug combination , generating reliable data that aids clinical trials , and understanding disease pathogenesis . I am a charismatic presenter with a strong experience in written and verbal communication that educates key stake holders , colleagues , and students . My previous experiences demonstrate a strong ability to drive progress and create a sturdy support for my team . Technical Expertise : Cell culture insect , mammalian and bacteria , co culture , Protein expression , purification and characterization , vector designs , cellular transfection infection , PCR , cellular assays , WB , chromatography : IEX , AE , HPLC , FPLC AKTA , radio active assays , ELISA , primary cell culture , capillary electrophoresis , lentivirus production , and more . Scientist Communicator Innovator Team player I will love to share more with you , let 's connect E mail : malapa03 gmail.com . Technologies :

carriers;proteins;characterization;expression;screening

Cheminformatics Scientist . . Extensive background in deep machine learning and computational chemistry biophysics with degrees in both Chemistry and Computer Science 2 years of experience in a startup developing and training deep generative models for small molecule and feature optimization Applied machine learning with computational experimental data for binding affinity prediction Various skill sets in molecular featurization , characterization , clustering Expertise in various free energy calculations for binding enzymatic catalysis free energy calculation Competence to utilize skills such as cloud parallel computing acquired in real scientific projects . Technologies :

Process Engineer GMP Operations . Since completing my postdoctoral project in June 2019 , I took some time off to travel across Asia , where I reconnected with my Indonesian roots and visited its many islands . I have made a point to keep up with the newest trends and technologies in the protein science field , while actively searching for opportunities where I can apply my background in membrane protein biochemistry to the biopharmaceutical industry . Currently , I m pursuing a German language course . . I am energized by challenges in membrane protein biochemistry that offer opportunities to understand the vital functions that proteins play in allowing living beings to survive . AREAS I EXCEL IN . For the last 10 years , I have worked on the frontier of structural biology and proteomics . I have shed light on new classes of membrane proteins , using structural biolog , and biophysical techniques to elucidate 3 D protein structure and characterize functionality . Drawing on my PhD in biochemistry , I have developed innovative systems , and protocols that optimized recombinant protein production , expression , and purification , and enabled structural determination and functional characterization of new classes of membrane proteins with high translational applicability in pharmaceuticals and medical research . My achievements have been documented in 4 publications , many of which have gained high visibility in the protein science field . MY ADDED VALUE . Having worked in international environments for a global Fortune 500 pharmaceutical company and 2 world ranked universities , I often receive feedback that my diverse knowledge of structural biology and biochemistry is one of my greatest assets . I take a conscientious and organized approach to maintain both high quality and quantity of meaningful data . I have also distinguished myself as a leader and valued team contributor , and enjoy working with and exchanging ideas with interdisciplinary scientific teams to drive momentum on challenging projects . MY CAREER TARGET . Since completing my PhD and postdoctoral work , I took time to travel through Asia and reconnect with my Indonesian roots . Now , I am eager to solve complex protein biochemistry problems and support the design and production of novel molecular therapeutics and technology developments for science based biopharmaceutical industries . . Technologies :

membrane proteins;characterization;structure

Assistant Ing nieur Biochimie Cryo EM . Etudes de prot ines intervenant dans la biogen se du ribosome . Production et purification de prot ines et complexes ribonucl iques Pr paration de grilles Cryo EM pour TITAN ou F20 Coloration n gative Acquisition d'images sur microscopes lectronique EPU . Passionn e depuis longtemps de microscopie , j'ai acquis au cours de mes exp riences professionnelles des comp tences en CRYO EM . Jeune et dynamique , j'ai quitt ma ville natale pour poursuivre mes r ves et continuer mon ascension en CRYO EM afin de contribuer aux recherches scientifiques . . Technologies : CryoEM

proteins;structure

Researcher , Biomedical Engineering . Research on the development of COVID 19 prophylactics and early treatments in collaboration with Fractal Therapeutics , a drug development company . Engineering cyclic peptides to block the SARS CoV 2 spike protein from binding to its receptor . Experience with computational modeling , molecular docking , and molecular dynamics software including Chimera , PyMol , FTMap , Maestro , Glide , Desmond . Biomedical engineering student with research and leadership experience . Strong interest in the area of drug discovery , drug delivery , and biomaterials .. Technologies :

Senior Scientist . . Senior scientist at Morphic Therapeutic with extensive experience in computational biology , bioinformatics , and machine learning , including developing algorithms and statistical models , establishing scalable and efficient pipelines , and designing visualization tools for large scale biological data analysis , with specialization in single cell analysis .. Technologies :

Doctoral Student . Research regarding lantibiotics and their modification enzymes . Protein purification structure investigations X ray , SAXS , Cryo EM , MALS etc . protein activity and interactions . . Technologies : Xray;CryoEM

proteins;interaction;structure

Senior Scientist , Computational Oncology . . Recent PhD graduate , using my optimization and machine learning skills to solve problems arising in cancer research . My background is in math , operations research , optimization and more recently ML . In the past few years my research has focused on models to identify the genetic causes of different drug responses in cancer patients and predicting drug response for different treatment options . . Technologies :

Scientist . Using in vivo Xenograft mouse model and in vitro cell based assays to develop small molecule therapeutics for the Ras Superfamily of Small GTPases screen and characterize candidate therapeutics . . Forward thinking biomedical research scientist with a strong background in molecular biology , biochemistry , cell biology , histology and in vitro assay development as well as xenograft mouse model with an excellent publication record . Highly skilled in mammalian , bacterial , insect cell and hybridoma cell culture experienced at using large scale mammalian cell culture bioreactor ; differentiation of embryonic stem ES cells , generation of MEFs and primary fibroblast cells , cell based and cell free assays , generating engineered cell lines , ELISA , Immunohistochemistry , fluorescent antibody technique . Proficient in isolation and analyzing DNA and RNA , molecular cloning , siRNA , CRISPR based gene editing technologies , AAV and lentivirus production , protein antibody expression and purification , SDS PAGE and western blot , qPCR , RT PCR , AKTA FPLC . Expert in mice and rat breeding and genotyping , dosing oral , IV , SC , IP , analysis of tumor growth , anesthesia , blood collection and dissection . Experienced in radiolabeled oligo extension DNA polymerase assay ; radio immunoassays . Creative , self motivated and passionate individual with easy integration in a multicultural environment and proven ability to meet tight deadlines by working in a fast paced work environment . I enjoy the challenges of learning and developing new experimental methods and applying these to scientific problems . I am very goal oriented and am flexible in attacking new problems . I have trained and supervised graduate students , laboratory fellows , postdocs and technicians . I am a great team player and have a strong ability to work both as an independent scientist and in a collaborative team environment .. Technologies :

carriers;expression

Postdoctoral Researcher . characterise cellular RNA and protein complex ; 3D structural determination by cryo EM ; ribosome related study . . PhD grade expert in RNA and protein biochemistry , molecular biology and structural biology . Structural biologist in cryo electron microscopy and crystallography . Expert in protein production , protein protein and protein RNA interaction . Excellent in independent research in conjunction with collaborative work . Self driven experimental design and performance , results analysis and interpretation , combined with literatures searching . Resilient team player with good sense of accountability .. Technologies : CryoEM

nucleic acids;proteins;interaction;structure

Computational Biology Scientist . . Expertise in high throughput data analysis in Bioinformatics . Integration of multi omics genomics , transcriptomics , proteomics . Customized data analysis and documentation . PhD in Bioinformatics from King 's College London Thesis title : Integrative Systems Biology analysis of protein interaction networks in normal haemopoietic cells and leukaemia . Postdoc in Hematological Medicine from Dana Farber Cancer Institute . Technologies :

Researcher . . I am an enthusiastic and interdisciplinary biomedical scientist with 15 years of experience in molecular biology , protein purification , biochemistry , and structural biology . Over the last decade , I have successfully carried out multiple projects in areas pertaining to capsid assembly , viral nanoparticle generation , and membrane transport . My core expertise lies in SAR studies using X ray crystallography , Cryo EM , and functional characterization using various biochemical and biophysical tools . I am goal oriented , curious by nature , and committed to solving challenging problems .. Technologies : Xray;CryoEM

proteins;characterization;structure

MS applications specialist . . 15 years of experience in Proteomics and Mass Spectrometry 15 years of experience in separation techniques : UPLC , HPLC IEX , RP , HILIC and 2DE Human stem cells differentiation expertise Involved in the study of several human pathologies : obesity , cancer , anemia , thalassemia , cystic fibrosis and multiple sclerosis . Expertise in cell culture : mesenchymal stem cells , adipocytes and osteoblast . Experience in new methods developing protein DNA interaction , membrane proteins and lipids oxidation Metabolomics expertise , in particular to study lipids and lipids oxidations Demonstrated scientific productivity through 25 publications in peer reviewed journals 3 first author and 22 co author Experience in grant application writing and submission Academia teaching and supervisor experiences 3 university courses and 9 students tutored Able to run and daily maintain all Thermo MS instruments : OrbitrapFUSION , Q ExactiveHF , Q Exactive , LTQ Orbitrap Velos ETD , and Triple Quadrupole TSQ Vantage . . Technologies :

membrane proteins;nucleic acids;interaction

Principal investigator Developing Degronomids for transcription factors at The SGC Frankfurt . We would like to develop PROTAC based strategies targeting the transcription factor FOXO , a key player triggering the development of many major age related disorders , including cancer , metabolic , and inflammatory diseases . . . Technologies :

molecular glues;developing;screening

Application Engineer . . Applied biophysicist with a background in the study of ion channel structure using Cryo Electron Microscopy and the creation of biological mimics . Experienced at working both independently and on cross functional teams . Skilled at leading teams and finishing projects on time . Direct involvement in the development of a medical device from concept to prototype , including work on the filing of the patent .. Technologies : CryoEM

membrane proteins;structure

Senior Principal Scientist , Computational Chemistry . . . Technologies :

Principal Scientist . . Computational biologist excited about analysis and interpretation of NGS data and its clinical applications . Proficient in NGS workflow pipeline including sequence alignment , SNP call and disease gene identification . Multi disciplinary background with deep understanding of biomedical science , population genetics and bioinformatics . Extensive experience with Linux UNIX systems and excellent skills in programming scripting languages . Great communication skills with people from biostatistics , software developments as well as other backgrounds . Extensive experience in managing , manipulating and analyzing large scale bioinformatics data from both internal and community sources 1000 G , UCSC etc . Familiar with current state bioinformatics pipelines workflows and statistical tools for NGS data analysis from determination of genetic variations to genetic mapping of disease susceptibility genes . Proficient in Linux UNIX , Mac OS and Windows , excellent in coding with Python , Matlab , Shell and C , experience with MYSQL database . Strong background in computational biology and biomedical sciences .. Technologies :

Principal Scientist . . . Technologies :

Senior Laboratory Technician . . I graduated with a Bachelor degree with honours in Life Sciences Biomolecular Research from the Utrecht University of Applied Sciences in 2015 , and obtained my Masters degree in Molecular and Cellular Life Sciences from Utrecht University in 2017 . Soon I started working as a junior researcher , and after two years I started as junior technician for Artemis Bio Support B. V. and expanded to ICT management . I confidently started a PhD trajectory on antibody glycosylation , which unfortunately I had to discontinue due to lack of time with a part time work week . However , my interest in research has not disappeared . I am keen to decipher the molecular and regulatory mechanisms behind infection , disease and pathogen clearance and am interested in structural biology and bioinformatics . My work relies on both having oversight on the complete structure , and keeping track of finer details . I have been described as highly organized , self motivated , pro active and naturally eager to learn new things . I am self taught in computer handling and ICT , and got expert training in order to fulfil my role as ICT manager in a small business . Currently , I am involved in multiple projects as senior technician . . Technologies :

biologics;developing

Bioinformatics Scientist . . . Technologies :

ENRICH Fellow . Conducted internal business development for the student run consulting group made up of advanced degree candidates , help find clients companies for paid consulting . Worked 10 hrs week along with Ph.D. research . Client : J J Center for Device Innovation CDI . Conducted market sizing and evaluation for acquisition of a nerve ablation technology through research and physician interviews . Position : Project Manager , 4 person team , 8 weeks . Client : Marker Therapeutics . Developed patent and IP applications for developing new T cell therapy production methods . Drew up schematics , wrote descriptions , landscaped current IP . Position : Project Fellow , 6 weeks Client : J J CDI . Established a workflow and acquired materials for a surgery auto registration software for live surgery guidance . Position : Project Fellow , 6 weeks . 10 years of hands on laboratory experience . Interested in developing fields of biological research , specifically virology and synthetic biology , translating scientific developments into profitable business applications , and improving the health and scientific community of the Choctaw Nation of Oklahoma .. Technologies :

proteins;structure

Senior Scientist . . I have been employed in the R D area at Novo Nordisk A S for the past 10 years , working on various peptide and antibody based projects in the areas of obesity , diabetes , hemostasis , inflammation and growth disorders . Here I have acquired in depth expertise within protein and peptide structure and interaction analyses using techniques such as SPR surface plasmon resonance , LC MS and 3D modelling . Also , I am experienced in generating humanization and germlining strategies for the design of therapeutic antibodies . During the past 6 years I have worked with Bioanalysis and LC MS MS assay development and validation for GLP studies . Keywords : Protein chemistry , SPR , Surface Plasmon Resonance , Biacore , KinExA , LC MS , ADME , quantitative LC MS MS , ELISA , Antibodies , 3D modelling , assay development , western blot , Enzymes , Biochemistry , GLP , Bioanalysis .. Technologies : SPR

antibodies;peptides;proteins;characterization;interaction

Computational Biologist . . . Technologies :

Senior Research Scientist . . Technology and human health have always been central focuses for my inquisitive nature . In my current position as Lead Bioinformatician for the Functional Genomics Platform OMXWare at IBM Research , I explore multi omics data for microorganisms . I use microbial genomics and the microbiome to expand our knowledge of human health , pathogenic bacteria , antimicrobial resistance , and food safety . . Technologies :

PHD Student . . Wellcome Trust funded PhD student studying the mechanism of amyloid formation on alpha synuclein using a wide range of techniques including NMR and electron microscopy . . Technologies : NMR

idps;characterization;structure

Doctoral Researcher . . My academic formation is in Biotechnology MSc and Pharmaceutical Science MSc . I worked for 3 years as a Research Associate in a biotech company Genmab , where I conducted research on antibody immunotherapeutics for cancer treatment . During those years my ambition was to understand better how efficient immune responses are generated and can be manipulated to fight aberrant conditions . . Currently , I am a PhD candidate in Immunology at the University of Liege and the focus of my research is the study of host virus interactions in the lung . More specifically , the aim of my project is to unravel some of the mechanisms that drive trained immunity by diverse viruses in the lung and the consequences of this innate memory in the fight of subsequent heterologous challenges . . . Technologies :

Research Associate Genetic Bioinformatics . . I have expertise in machine learning and bioinformatics . . Technologies :

Senior Scientist . Discover oncogene induced vulnerabilities synthetic lethalities in the fatal pediatric glioma diffuse midline gliomas , and evaluate therapeutic efficacy of agents targeting the specific vulnerabilities . Studies to understand the mechanism of dependency , and mechanism of action and resistance to therapeutic agents . Studies evaluating replication stress induced DNA damage and genomic instability . 1 . Ph . D in Molecular , Cellular , Developmental Biology 2 . 12 years of experience in Cancer Biology Research 3 . Expertise in pre clinical in vitro and in vivo studies , therapeutic target discovery and validation 4 . Experience and expertise in omics technology , cell based assays , DNA damage response and repair pathway studies 5 . Track record of working in a highly collaborative environment 6 . Strong publication and presentation record . Technologies :

. . Masters of Science degree in Bioinformatics having wet lab experience on microbial fuel cell technology and on the identification of extracellular membrane proteins that involving in electron transfer mechanisms NCBI and UniProt dependent screening , GO annotations , PPI construction and evolutionary tree construction by MEGA As a student of bioinformatics , have good knowledge of R and Perl scripting for biological data analysis . During the first M.Sc . project in Bangladesh , have 1 year work experience in a wet lab particularly in microbial fuel cell construction and operation , nanoparticle synthesis by this technique and its characterization and also on bacterial and fungal cell culture . Presently focusing on PhD position related to microbiology , microbial fuel cell , gene networking , evolutionary biology , bioinformatics , system biology , cell biology and environmental bioengineering .. Technologies :

Computational Biologist . . . Technologies :

Senior Biomarker Assay Scientist . Develop , Validate and implement the Immunophenotyping biomarker assay using flowcytometry for clinical trials Phase I 2 3 under regulated controlled environment . Develop , Validate and test the clinical pharmacodynamics biomarker using Ligand Binding Assay Matrix : Plasma Serum Urine Phase I 2 3 under GLP GCP compliant . Subject matter expert in multiple assay platforms MSD ECL Luminex ELISA ELIA and working knowledge of Gyro lab ELISPOT Roche Cobas . Manage collaborative relationships with clinical study leads , project managers , platform representatives , and key internal and external stakeholders , to advance portfolio projects . Evaluate new technologies to streamline the workflows for continues improvement of clinical development programs . Contribute to study design from the perspective of sample collection , processing and data reporting . Lead the project in a hybrid environment to support the light speed clinical drug development programs . Implement the robust quality control checks on analytical instruments and maintain instrument operation , including sample preparation , analysis , end to end sample management and data reporting . Ensure that cross functional team receive the results within timeline or before the closeout action plan . Manage and encourage the clinical assay scientist to achieve the robust and reliable assay performance to sustain or exceed the team quality requirement . Support the data management team to streamline the data delivery with quality mindset . . A 12 years of translational research and 7 years of clinical bioanalytical assay development operational experience . Ready to accept the new challenges while ensuring all planned goals meet the leadership expectations . Subject matter expert in pharmacodynamics or disease related biomarkers assay development and method validation under GCP GLP guidelines Proof of Concept Proof of Mechanism studies . Critical team player in clinical assay operational management to support the first in human FIH phase 1 II clinical trials and advanced the program into Phase III exploratory to primary assay . Led and validated several immunoassays to support clinical study team requirements partial or full validation under FDA EMA ICH guidelines . Successfully developed in house ultrasensitive ligand binding method 40 cost reduction , validated and supported the first in human FIH phase 1 II clinical trial and advanced the program into Phase III . Strategic thinker and liaison between data management , project management , discovery team and clinical development team to support the bioanalytical assay implementation from feasibility to clinical assay validation . Experience in Clinical Bioanalytical Project Management Clinical Bioanalytical Method Development Clinical Bioanalytical Method Validation Clinical Sample Management Vendor Management Supply chain inventory management Bioanalytical Method Plan Protocol Report writing Bioanalytical Study Plan Report Writing SOPS Work instructions Test Method Development writing Quality Management Risk Based Biomarker Assay Feasibility Assessment Development Biomarker Assay Validation Biomarker assay Troubleshooting Analytical Instruments management Process Improvement methodology . Technologies :

antibodies;biologics;proteins;characterization;expression;quality;screening

Sr . Research Associate . Sr . Research Associate in the Antibody engineering team . . Enthusiast , driven and eager to learn personality . Experienced in the fields of . biotech . molecular biology and genetics . bioinformatics . data analysis . operational co rdination and planning . coaching . Technologies :

antibodies;engineering

PhD Student . . I am a PhD candidate studying mitochondrial associated proteins using cryo electron microscopy .. Technologies : CryoEM

proteins;interaction;structure

PhD student in Molecular and Structural Biology . Preliminary thesis title : TAC architecture in Trypanosoma brucei In my position as PhD student in the groups of Beno t Zuber and Torsten Ochsenreiter , I aim to characterize the mitochondrial DNA anchoring and segregation machinery of Trypanosoma brucei . Using cryo electron tomography and single particle cryo EM , I analyse the complex in high resolution , to gain insightes in its organization and mode of action . As trypanosomes only posess a single mitochondrion , with a single mitochondrial DNA network per cell , mitochondrial DNA inheritance is highly divergent from these processes in other well studied model organisms . The TAC is an interphase between the highly conserved , and the uniquely divergent . It is built of a set of trypanosomatid specific proteins that anchor the mitochondrial DNA network to the basal body of the flagellum . . . Technologies : CryoEM

proteins;structure

Postdoctoral Researcher . Study the functional and mechanistic aspect of effector proteins from Legionella using structural Cryo EM and cell biology based approaches . . Technologies : CryoEM

proteins;structure

Director of Computational Biology and Data Science . Use data engineering , computational biology , and software engineering to convert a multiomic dataflux into ecosystem based diagnostics and therapies . Poop for the Cure . Industrial physicist with strong record of combining creativity and mathematical rigor in diverse areas of science and technology . Accelerates development of emerging technologies by drawing upon and connecting fields . Simplifies development , analysis , and communication of complex systems with quantitative methods that identify key parameters . Fifteen scientific publications . https : scholar.google.com citations user CxHHdokAAAAJ hl en Experience includes : Immune system dynamics High performance computing 149 ; Far from equilibrium , low number , chemical dynamics Computer architecture Biometrics Biochemical network inference Semiconductor processing Bio photonic imaging Certified welder . Technologies :

Associate professor , PhD . My responsibilities or tasks as an associate professor permanent faculty member have so far been : teaching pharmacology , supervision of Master and PhD students , acting as course director , Head of the teaching committee , conducting research of high quality , presenting scientific data at national and international meetings conferences , networking , publishing research results in high ranking international scientific journals , contributing to book chapters , applying for and attracting external grants , member or Fellow of prestigious international scientific societies , member of reviewer and editorial board as a courtesy to the scientific community , organizing and chairing scientific meetings and PhD defenses , member of the Committee for Research and Innovation . . I am a very driven , highly ambitious and productive researcher with innovative approach to research and teaching within the field of cardiovascular physiology and pharmacology . My goal is to become a Chief Executive Officer CEO for research and development or become a member of Executive Leadership Team at one of top 10 biotech and pharmaceutical companies worldwide . Throughout my academic career , I have been focusing on the regulation of vascular tone in health and disease diabetes type I II , stroke , hypertension , congestive heart failure , migraine and age related changes . Coronary arteries are densely innervated by sensory nerve endings containing calcitonin gene related peptide CGRP . CGRP is a potent naturally occuring 37 amino acid vasodilatory neuropeptide which is released from the perivascular sensory nerve endings in the wall of flow regulating intramural coronary arteries during hypoxia and by low pH levels in the myocardium , thus suggesting a vasodilatory role under ischemic conditions . So far , our studies demonstrate a larger CGRP receptor density in resistance arteries internal lumen diameter 200 m compared to larger conductance arteries internal lumen diameter 200 m , indicating that receptor distribution , calcium handling , ion channels and second messengers may be finely adjusted within the circulatory system , probably reflecting the physiological demands on the vascular segments . CGRP receptor consists of three components , calcitonin receptor like receptor CLR , a specific chaperone called receptor activity modifying protein 1 RAMP1 and receptor component protein RCP . A novel family of chaperone proteins , called RAMPs RAMP1 , RAMP2 and RAMP3 were identified as proteins escorting CLR to the plasma membrane to generate either CGRP when associated with RAMP1 or adrenomedullin receptors when associated with RAMP2 or RAMP3 . CLR belongs to class B of the G protein coupled receptor GPCR family and is linked to Gs protein . Our studies will shed light on the complexity of CGRP receptor pharmacology as well as its complex signaling pathway , thereby helping us understand its physiology as well as its role under different circulatory complications such as stroke , ischemia , hypertension and migraine . Techniques and specialties : Myography wire and pressurized , Electric field stimulation , Langendorff perfused heart preparation , fluorescence microscopy , stereology , measurement of intracellular calcium concentration , Investigations of G protein coupled receptor signaling pathways .. Technologies :

Senior Scientist . . Drug product expert with 6 years of pharmaceutical industry experience in formulation and process development of early stage and late stage drug development projects . Expertise in scale up and technology transfer , process validation , GMP production of clinical and validation batches . Involved in successful US FDA EU EMA filings of complex injectable products . Also possess knowledge and experience on analytical methods for drug product and polymer characterization . . Complex injectable formulations Microspheres , liposomes , nanoparticles , adeno viral vaccines . . Technologies :

carriers;formulation;quality

Principal Scientist . . Providing mass spectrometry expertise to a multidisciplinary analytical team to contribute to the characterisation and analysis of therapeutic biologics : mAbs , non mAb biologics , conjugate vaccines , nitrosamines , oligonucleotides mRNA and lipid .. Technologies :

antibodies;biologics;nucleic acids;characterization

Cryo EM Microscopist . . Marcelo Alexandre de Farias is a cryo electron microscopist cryo EM specialist . He received his PhD in Sciences in 2014 from University of Campinas . Between 2015 and 2018 he specialized in metrology , mainly on methods for determination of particle size ISO IEC 17025 and evaluation of measurement uncertainty using SEM and TEM . He has already received two awards for his scientific production and he is author co author of 31 peer reviewed papers .. Technologies : CryoEM

proteins;structure

Senior Research Development Scientist . . Anna Spanopoulou studied Chemistry at the University of Ioannina in Greece and received her Diploma in 2010 . She received her M. Sc . from the University of Patras in Greece at 2012 . Her M. Sc . thesis concerned the synthesis of conotoxin analogues . She completed her PhD in the group of A. Kapurniotu at TUM in 2019 . Her PhD studies focused on the design , synthesis , and study of conformationally constrained peptides as amyloid inhibitors . . Technologies :

idps;peptides;developing

Principal Scientist , Project Lead . . Expert for pharmaceutical drug discovery , high content screening and preclinical pharmaceutical research . Areas covered : advanced microscopy , high content screening HCS , automated image analysis , laboratory automation , laboratory robotics , high throughput screening HTS , advanced cell culture . Target deconvolution and target identification . Nuvisan PROTAC panel . Main indication areas covered : Oncology , Ophthalmology , Gynecological Therapies , Lung and Kidney diseases . Creative , collaborative and highly self motivated team player in academic and industry research institutions with proven track record several publications as last author , publications in Cell and Nature , several patents , covering a wide range of topics in molecular and cell biology . Several years of proven experience as project manager project leader in multi functional , multi institutional life science research projects and as open and flexible team player in international life science research projects . See e.g. https : www.photonikforschung.de projekte lebenswissenschaften projekt promebs.html . Leadership and development of direct reports and academic e.g. Master , PhD , Postdoc students . As part of the open innovation community consulted biotech and pharma companies in the field of life sciences see e.g. https : www.businesswire.com news home 20110609006465 en InnoCentive Honors 2010 Top Solvers Introduces Groundbreaking and www.innocentive.com top solvers 2010 Communication of complex science to specialists , journalists and lay audience .. Technologies :

molecular glues;screening

Scientist . Pharmaceutical Development Biologicals Early Stage Formulation Process Development . Curious biochemist biophysicist with demonstrated expertise in protein DNA biochemistry and state of the art single molecule fluorescence methods . Problem solver with strong communication skills , who worked in interdisciplinary , dynamic , and international teams in Israel , Germany , Belgium , and the US . . Technologies :

biologics;formulation

Staff Physics . . . Technologies :

Bioinformatics Data Scientist . . 10 years bioinformatics experience leading and contributing to projects in sequence analysis and gene expression analysis in the biotech industry and academia . I have recently updated my skills for the Data Science field . Perl , Python , R , Unix , SQL , Genomics , Statistics , Octave , Machine Learning , Data Science , Next Generation Sequencing Analysis and Pipeline , Git , Docker , Bioconductor , AWS , Linux , Bash scripting , ggplot2 , dplyr , Gene Ontology , Algorithm Development , NGS , Statistical Analysis , datasets , data quality , sequence alignment , genome analysis , k means clustering , random forests , statistical modeling , biomarker discovery , object oriented programming . Technologies :

Post doctoral Researcher , European Molecular Biology Laboratory EMBL , Heidelberg , Germany . Developed protocol for expression of proteins in insect cells and in vitro reconstitution of large protein RNA complexes Currently performing cryo EM studies of protein RNA complexes involved in Drosophila dosage compensation Combining X ray crystallography , NMR , cryo EM data to gain structural insights into large protein nucleic acid complexes . Structural biologist with 12 years of experience in the field and 3.5 years of postdoctoral experience Extensive background in structural biology and biochemistry resulting in 19 publications in peer reviewed journals including 9 first author papers Expertise in X ray crystallography of protein small molecule complexes Experience with the study of protein ligand interaction using NMR approaches Experience with structure based small molecule design and NMR based fragment screening Comprehensive knowledge of biophysical techniques for protein ligand studies including ITC , SPR , thermoflour , MST , CD spectroscopy and FP assays . Experience with cryo EM of protein RNA complexes Extensive communication , teamwork and scientific writing skills developed through collaborations , conference talks , bench and teaching duties . Technologies : Xray;CryoEM;ITC;SPR;MST;NMR;FP

nucleic acids;proteins;small molecules;interaction;structure

Head of Computational Biology . I lead a world class team of computational biologists , software engineers , and statisticians to discover new drugs for neurodegenerative diseases , including ALS , Parkinson 's , and Alzheimer 's Disease . Our team develops algorithms and software that integrates multiple types of genomic , transcriptomic , and phenotypic data in order to reveal molecular mechanisms that cause disease pathology . We computationally predict small molecules and gene perturbations that can therapeutically reverse these mechanisms ; we test our predictions in living models , including human cell cultures and rodent models . . I lead a world class team of computational biologists to discover new drugs for neurodegenerative diseases , including ALS and Parkinson 's Disease . My work combines a wide range of methods , including genomics , systems biology , machine learning , and supercomputing . I am also a full stack web developer . I have twenty years experience software engineering with a wide range of programming languages . I am equally comfortable engineering server side engines , scalable databases , and user centric web interfaces . Depending on the day and project , I am a scientist , leader , software engineer , big data analyst , teacher , and team player . Please message me for my recent CV and publication record .. Technologies :

Senior Machine Learning Researcher , Artificial Intelligence Products Group , Intel Corporation . . I am an AI research scientist and technical leader with over a decade s worth of expertise in building , analyzing , and accelerating large scale machine learning models and their hardware implementations . In addition to making extensive contributions to machine learning frameworks within startups and large companies , I also led data science engagements in the automotive and agricultural sectors . I am involved in various outreach programs aimed at exposing kids from socio economically underprivileged backgrounds to robotics and hobbyist autonomous vehicles . I am an avid enthusiast of hacking electronics . Specialties : Machine learning , optimization theory , Bayesian inference , dynamical systems , and statistical physics . Technologies :

Director , CMC Biologics . . Extensive hands on experience within biotech covering early and late phase R D and technology transfer . Key responsible for lead candidate selection , process development and technology transfers to CMOs for GMP manufacturing of drug substance and drug product as well as biochemical analysis and characterisation of protein therapeutics including monoclonal antibodies Solid experience from with working globally in cross cultural teams through participation in numerous project teams from the US , Latin America , across Asia and within EU . I hold a M.Sc . in biochemistry and a Ph.D. degree in protein chemistry from the University of Copenhagen . Specialities include : Idea generating Extensive product and process understanding within biopharmaceuticals Process development , scale up and technology transfer Front end studies , feasibility studies and business cases Business development . Technologies :

antibodies;proteins;characterization;expression

Science Manager . Characterization and to a smaller extent purification of enzymes for application testing in food and detergent industries . Chromatographic techniques include HIC , SEC , IMAC , HCIC , and IEC on kta Explorer systems controlled by Unicorn software . Characterization include SDS PAGE , activity assays , IEF , and interpretation of data from MS , N terminal sequencing , amino acid analysis , DLS , and DSC DSF . Co supervisor for industrial PhD student . . Protein chemist with international work experience and experience from project work related to a broad range of industries which apply biotechnological solutions . Main focus has been on protein purification by chromatographic techniques and characterization of proteins activity and stability at process relevant conditions . I enjoy working together with people with different cultural and scientific backgrounds .. Technologies : SLS DLS;DSC;DSF

enzymes;proteins;characterization;stability

Director , Department Structural Biochemistry . . I am a structural biologist whose research focuses on understanding molecular mechanisms underlying cellular processes in the healthy and diseased organism . With my research group , I use a multi disciplinary approach , including biochemical reconstitutions , high resolution electron cryomicroscopy cryo EM , and X ray crystallography primarily to investigate the structure of macromolecular complexes that play a crucial role in cell physiology , with a particular emphasis on toxin mediated membrane permeation and membrane homeostasis . Furthermore , the aim of my group is to understand the molecular details of muscle contraction and the dynamics of the eukaryotic cytoskeleton . A detailed understanding of these processes is of great importance as they ultimately serve to develop pharmaceutical measures to combat disease .. Technologies : Xray;CryoEM

proteins;structure

Senior Manager , Observational Research Data Analytics . . SUMMARY A decisive and science driven bioinformatics professional who efficiently blends skills in biology , computer science , and statistics to create and deliver unique algorithms , tools , and pipelines for solving problems emerging on the cutting edge of data driven biomedical research . Outcome driven and energetic innovator with a proven track record in large scale engineering , analytics , manipulation , and interpretation of high dimensional coding and non coding transcriptome data using data integration , network analysis , machine learning , pattern mining , and statistical computing . KEY QUALIFICATIONS Strong proficiency in algorithm design and data pipeline development Profound experience in software development in R and Java Excellent verbal communicator with academic teaching experience Highly experienced in collaborating with bench scientists to consolidate data analysis with experimental design Scientific track record with first , co , and senior authored articles in top tier peer reviewed scientific journals Deep expertise in generation , analysis , and modeling of complex multivariate single cell data . Technologies :

Research Scientist III . . PhD in biochemistry with 20 years of multidisciplinary biomedical research experience covering oncology , immunology , complement biology , innate immunity , biomarker development , immunotherapy target discovery , infectious disease , resulting in 2.2 million grant funds from government and private sector , 1 awarded patent , 1 patent application and 19 peer reviewed scientific publications . 20 years of experience in working with protein . Expertise in characterization of protein protein interactions 15 years of translational research experience . Experience and knowledge on drug development process from discovery of a target , proof of concept , patent application , to develop an immunotherapy , and to seek collaboration from industry in order to transform our discovery into a therapeutic drug . 15 years experience of complement research in the area of infectious disease . Discovery of bacterial complement inhibitors targeting C1q , C3a , C3c , C3d and C5 ; and identification of mechanism of action for each molecule . 3 years experience in preclinical drug discovery and development of complement inhibitors for treatment of complement dysregulated diseases . On a personal side , I love to experience different culture of different countries . I love travel , hike and play badminton . I have won numerous trophies in the tournament . Scientific Specialties Drug discovery experience , Immunology , Complement Biology , phagocytes , Bacteriology , Microbiology , Genetics , Molecular Biology , Cancer research , Vaccines , Antibody Therapy . Small Molecule Therapy .. Technologies :

proteins;small molecules;characterization;interaction;screening

Associate Scientist L2 , CMC Pharmaceutical Development Technology Analytics . Analysis of the quality and stability of lead Nanobodies during pre clinical and clinical development incorporating numerous techniques including Reversed Phase , Size Exclusion and Ion exchange U HPLC chromatography , capillary electrophoresis , Dynamic Light Scattering DLS , Micro Flow Imaging MFI , Light obscuration , osmolality and viscosity measurements , endotoxin testing , Host Cell Proteins assays , Method Development . In process stability studies , stress testing and the development of stable formulations . Control the quality and consistency of Nanobody productions and thereby assist in the development of a large scale manufacturing process for a specific lead Nanobody . Physico chemical characterization of Nanobodies , identification of product variants and investigation of degradation pathways . Master in Biochemistry and Biotechnology from the University of Ghent , Ghent , Belgium with a major in Biomedical biotechnology and minor component in Structural Biochemistry . B. Sc . Honours Degree in Biochemistry , Molecular biology and Biotechnology from Dublin Institute of technology , Dublin , Ireland . . . Technologies : SLS DLS

antibodies;characterization;quality;stability

Health Sensing Data Scientist . Developing and tuning algorithms for extracting insight from sensor data and optimizing performance across a large user base via analysis and automated learning . . I am interested in methods of acquiring and utilizing knowledge , both how this is done by living beings from cells to humans and how we might reproduce it in artificial systems . My graduate work focused on applying this line of inquiry to protein structure inference , and determining how we can utilize experimental data to its full extent . I have since worked as a data scientist building automated approaches for interpreting health data from medical records at Lumiata and from sensors at Apple . Specialties : machine learning , deep learning , computational structure prediction , data analysis . Technologies :

CRO Study Director . . Dick Terwel holds a Ph . D. in Medical Sciences and is an expert in animal models for Alzheimer s disease . His drive is to understand pathological mechanisms to be able to help find a cure for this devastating disease . . He developed several animal models for tauopathy and neurodegeneration at KU Leuven . In depth analysis of these models and of crosses of different transgenic mouse lines has helped to further elucidate disease mechanisms and validate the amyloid cascade hypothesis of Alzheimer s disease . Relevant aspects of Alzheimer s disease on the basis of research in mentioned models and crosses are synaptic changes , clearance of A , neuroinflammation , spreading of tau pathology , interaction between Abeta and tau pathology . The animal models and yeast based models formed the basis for spinning off reMYND . As the CRO Study Director at reMYND he is responsible for client consultation and all operational aspects of proof of concept or hypothesis testing studies . Clients include big pharma , biotech and academic groups . . Technologies :

idps;formulation

Associate Principal Scientist . Biophysics support for drug lead generation projects . Biomolecular NMR . Fragment based screening . Hit conformation and drug mode of action studies . . Technologies : NMR

small molecules;interaction;screening;structure

Chemistry Consultant . . Experienced R D scientist , senior manager and innovator in the areas of synthetic polymers and antibody protein bioconjugation . Co founder of PolyTherics , UK now Abzena . Developed and led the science team at PolyTherics and later the Chemistry team at Abzena over 15 years . Extensive experience of managing multi disciplinary teams and projects across different locations . Part of the management team that grew PolyTherics as a successful start up from only 2 employees . Track record of innovation and commercial exploitation of scientific research . . SIGNATURE STRENGTHS . : : Development Intellectual Property Protection Of Proprietary Technologies . : : Leadership Delivery Of Multi disciplinary Projects Including Service Projects With International Collaborators . : : Scientific Leadership Innovation . : : Management Of Patent Portfolio . : : Scientific Support for Business Development . SCIENTIFIC EXPERTISE EXAMPLES . : : Polymer Synthesis Derivatisation . : : Antibody Drug Conjugates ADCs . : : PEGylation of Therapeutic Proteins and Peptides . : : Chemical Fusion of Antibodies , Proteins and Peptides . : : Protein Labelling Biotin , HRP . : : Radio Labelling . : : Organic Synthesis of Novel Conjugating Reagents . : : Novel Adhesives . : : Protein and Peptide Purification Characterisation . : : Biological Characterisation and Bioassays of Conjugates . Technologies :

antibodies;developing;engineering

Pharmaceutical Specialist IPT Nexplanon . Ensure that pharmaceutical production within Integrated Process Team Nexplanon is performed in line with current GMP guidelines . Key activities : . Deviation management , Risk Management , Change Control , RCA analysis , Problem solving , Continous improvement , CAPA management , Document management SOP , GMP , Complaint investigation and handling . . Enthusiastic Scientist Manager with a broad expertise in antibody sciences , cell biology , molecular biology and assay development within R D in the field of immunology and oncology . In the role of Safety Officer gained a lot of experience in Environment Health Safety EHS , compliance with legislation and regulation concerning contained use of genetically modified organisms GMO and ARBO related matters . Because of my versatility , quality mindset , high adaptability and eagerness to learn , I am a suitable candidate for various pharma and biotech related functions . I have a high sense of responsibility , good organizational skills and work very accurately . I like to work in a team but am very capable of working independently . Versatile Focus on Quality Organized Accurate Eye for detail Team player Communicative . . Technologies :

PHD Student . Studying protein complexes involved in mRNA processing with X ray crystallography and cryo EM Group of Prof. Martin Jinek Supported by Boehringer Ingelheim Fonds Fellowship 2018 2020 . Structural biologist and biochemist with 9 years experience in basic research . Passionate about protein architecture function and solving molecular puzzles . Currently wrapping up my PhD research in the exciting field of mRNA processing . Looking for new challenges in the life sciences , diagnostic , or pharmaceutical industry .. Technologies : Xray;CryoEM

nucleic acids;proteins;interaction;structure

Senior Field Data Scientist . . Data scientist skilled in the application of quantitative data analysis to real world problems , with a focus on biomedicine . Specialties : Computational biology and bioinformatics Analysis of high dimensional data Gene expression microarray analysis HER2 breast cancer Excellent communication and teamwork skills Conveying complex science to lay audiences . Technologies :

Senior Scientist . . Awarded Summa cum laude Excellent for Ph . D thesis focused on biological characterization of . small molecules . 5 years of expertise in assay development , high throughput small molecule screening and . characterization , target identification and validation . 7 years of multifunctional regulatory knowledge and a strong technical background in biological . and pharmaceutical sciences . Language proficiency : English Fluent , German B1 , Hindi and Marathi Native . Key specialties : mass spectrometry based proteomics , assay validation and execution , pre clinical drug discovery , target identification and validation , protein protein interaction , biological screening , mode of action studies , data analysis , strong interpersonal and cross cultural skills , entrepreneurial , project Management . . Technologies : Xray

proteins;small molecules;screening

Senior Biological Data Scientist . . I am graduating with my PhD in Biomedical Informatics in August of 2021 . As a PhD level computational biologist and data scientist , I have extensive experience applying my strong technical skills to complex biological datasets . During my PhD , my research focused on examining how sex and hormones contribute to variability in gene expression and genomic data . I also am passionate about teaching and mentoring students in the sciences .. Technologies :

Principal scientist . Neuroscientist at H. Lundbeck A S . Experienced researcher and project manager . 8 years of industry experience . Specialist in ex vivo and in vivo models of protein aggregation , neurodegeneration and inflammation , with extensive knowledge of neurodegenerative and innate immunity pathway regulation . I have experience in grant writing , overseeing and writing applications for animal experimentation , has been involved in several large EU collaborations , both from the academic and industry side FP7 and IMI2 projects . Coordinated or contributed to several international academic research collaborations and pharmacological and diagnostic development projects involving multinational pharma companies . I am interested in a research and or supervisory position within industry allowing me to develop as a scientist and as a leader . Specialties : Leadership , strategic planning , knowledge based decision making , communication , technical writing , pharmacology , drug discovery , in vivo and ex vivo models of neurodegeneration and inflammation . Assays for monitoring protein aggregation in cells or ex vivo .. Technologies :

idps

Principal Bioinformatician . I work on understanding pathogen detection and emergence in the microbiome , and high quality reproducible research practices for genomic surveillance . I lead the software development of the JUNO project , a genomic data tracking and data sharing platform for the global surveillance of the pathogen Streptococcus agalactiae . I develop bioinformatics pipelines and informatics training for the Bentley group and collaborators of the Global Pneumococcal Sequencing Project . My research interests have been on detection and prediction of emerging pathogens from the microbiome , with a focus on the interactions between antimicrobial resistance and mobile genetic elements in metagenomes . . Leader in bioinformatics with specialist technical expertise to build high value products and services for public health experts and epidemiologists . Committed and collaborative leader who engages with partners and stakeholders to expand genomic surveillance globally . Talented strategic thinker who applies strong , principled goals to drive effective and fair research practices .. Technologies :

Director Of Bioinformatics . . Bioinformatics scientist with broad experience in building Gene Regulatory Networks GRN 's and NGS such as ChIPSeq and RNASeq . Specialties : Microarray analysis , Gene Regulatory Network GRN , pathway network analysis , NGS Illumina RNA Seq ChIP Seq Analysis , mathematical modeling , Bayesian Network . SQL , Matlab , SAS , Perl scripting , BioPerl , BLAST .. Technologies :

Scientist Protein purification characterization Analytical Biophysical methods development . Designing , conducting and troubleshooting a diverse range of molecular biology , biochemical and biophysical experiments to study the structure and function of Hsp90 protein . Molecular Cloning , expressing and purifying Hsp90 protein from prokaryotic and eukaryotic host using fast protein liquid chromatography AKTA FPLC . Conducting biochemical analysis of Hsp90 multi protein complexes using chromatography , gel electrophoresis , western blot techniques . Characterizing Hsp90 enzyme structure and function using fluorescence microscopy , Atomic force microscopy and ATPase activity assay . Developing a custom built fluorescence microscope to visualize fluorescent dye labelled protein single molecules . Constructed and Taught seminars and practical courses for Master 's students . . I am a highly motivated protein biochemist with 10 years of expertise in process development for recombinant protein expression , purification , and characterization using chromatography , biochemical and biophysical techniques . I am an interdisciplinary scientist leading multiple projects in protein DNA characterization , formulation , protein ligand , and protein drug interaction , DNA nanoparticle drug interaction , lipid based drug delivery , and drug discovery using analytical and biophysical techniques . I have successfully led multiple projects in biochemistry , molecular biology , structural biology , and cell biology . I have a strong background in science communications and scientific grant writing as demonstrated by 15 publications , conference presentations , invited talks , and awards from funding agencies . Technical skills : Biochemistry : Protein expression protein purification size exclusion chromatography SEC ion exchange chromatography affinity chromatography FPLC HPLC gel electrophoresis SDS PAGE protein crosslinking enzyme kinetics . Molecular biology Cell biology : Cloning nucleic acid extraction and purification PCR colony PCR transformation transfection western blotting bacterial cell culture Hela cell culture virus culture and virus purification sterile technique cell culture media preparation . Biophysics : Fluorescence assays circular dichroism spectroscopy CD dynamic light scattering DLS UV vis absorption spectroscopy analytical ultracentrifugation AUC microfluidics isothermal titration calorimetry ITC FTIR Structural biology : TEM , Cryo EM sample preparation Cryo EM data processing Relion Hands on experience on NMR spectrometers Bioinformatics Data Science : Statistical data analysis Origin 8.5 Image Analysis Image quant and Image J Protein structure and sequence analysis ExPASy , PyMol Chem Draw C Linux Interpersonal skills : Problem solving and scientific creativity multitasking time management excellent written and verbal communication organized and detail oriented deadline conscious ability to handle high volume demands I am looking forward to an opportunity where I can utilize my skill sets to grow as a professional and be resourceful to my employer . I am actively seeking new roles and willing to relocate for the right opportunity . Feel free to contact for consultation , science writing related enquiries tanumoy.biochem gmail.com . Technologies : CryoEM;ITC;SLS DLS;AUC;CD;NMR;FP;FRET

proteins;small molecules;characterization;expression;formulation;interaction;structure

Senior Scientist . . Genomics and genetics scientist with extensive molecular biology expertise and a goal to harness biological information for a healthier future . Technologies :

Postdoctoral Researcher . Setting up and maintaining the Two Electrode Voltage Clamp with Fast solution perfusion system ; Membrane protein expression in Mammalian Cells via viral infection ; Structural analysis of purified membrane proteins via Negative Stain Electron Miucroscopy . I graduated from the Indian Institute of Technology , Kharagpur , India , with Bachelors and Masters degrees in Biotechnology and Biochemical Engineering , in 2008 . Thereafter I pursued a doctoral degree at the University of Wisconsin Madison , graduating with a Ph.D. in Biophysics in June 2014 . Since then , I have been a post doctoral researcher working at the Vollum Institute , Oregon Health and Science University , Portland , with Dr. Eric Gouaux . In my graduate research I have published 10 peer reviewed articles which have accrued more than 100 citations so far . I have received multiple awards for my research and several of my papers have received glorifying reviews commentaries published in leading international journals , press release articles , etc . More generally speaking , my graduate training polished my analytical skills and problem solving ability , while honing my presentation communication skills . I have guided several group members in their research and managed over 3 multi disciplinary research projects . While my graduate training was in electrophysiology , my postdoctoral research work employs a wide variety biochemical and structural biology techniques , such as membrane protein purification , protein ligand association studies , cryo electron microscopy , etc . I am a passionate , determined and hard working individual who loves to crack new and challenging problems and avails every opportunity to learn and implement new strategies , while constantly striving to achieve perfection .. Technologies : CryoEM

membrane proteins;expression;interaction;structure

Staff Scientist . . I am interested in Machine Learning , AI , Data Science and Computational Biology . My research focus is Causal Inference and its application to data driven areas like Biomedical science .. Technologies :

iNANO Cryo EM Facility Manager . . . Technologies : CryoEM

Quality Control Scientist I . Performs quality control testing of in vitro diagnostic polymerase chain reaction PCR Accula SARS Cov 2 test cassettes , swabs , and buffers , including stability and validation testing Completes written real time documentation during testing Complies with Good Laboratory Practices GLP and Good Data Practices GDP Understands Good Manufacturing Practices GMP Conducts Out of Specifications OOS investigations and initiates Non Conformance Material Reports NCMR Supports Deviations , Change Orders COs , and Corrective Action and Preventative Actions CAPAs Reviews testing documentation for submittal to Quality Assurance QA Proposes and implements process improvement ideas to leadership regarding document changes and lab processes resulting in fewer errors , increased efficiency , and reduced waste Supports Research and Development R D team in assay development for new product lines . Highly motivated and enthusiastic quality control scientist who excels in a fast paced , collaborative work environment .. Technologies :

biologics;quality;stability

Lab head and Project Leader . Laboratory Head in Pharmaceutical Sciences in pharma Research and Early Development pRED . . My group works on predicting and understanding the pharmacokinetics of therapeutic antibodies by developing novel cellular assays and analysis methods . . As DMPK PD project leader I 'm providing scientific and strategic leadership in project teams with a focus on large molecules . Here I aid in the selection and timely development of new drug candidates through close interaction with therapeutic areas and affiliated non clinical , clinical and regulatory functions . . Extensive background in DMPK of therapeutic antibodies , biochemistry and biophysics of antibodies and membrane proteins with highly developed skills in project management and assay development . Expert in protein engineering , large molecule pharmacokinetics and transporter studies . History of team based success , including project management and leadership roles in scientific research and consulting . Excellent written , illustrative , and verbal communication skills cultivated through scientific publications , presentations , grant writing , team based consulting , training laboratory personnel and consultants , mentoring scientists , and teaching experience . Motivated by solving complex problems , working with others to achieve project goals and learning new things . . Technologies : FRET

antibodies;membrane proteins;characterization

Senior Scientist . CMC Drug Product Development . I am a PhD in Pharmaceutical Sciences with a broad field of experience from university , pharmaceutical industry and regulatory authorities . University research projects were undertaken in Denmark , USA and Australia . My main areas of professional experience cover Formulation and process development of oral solid dosage forms including statistical design of experiments , stability studies , specification setting , method validation and preparation of regulatory CMC documentation for clinical trials and marketing autorisation ADME in vitro and ex vivo studies of both small and large molecules , mainly focused on the enhancement of gastrointestinal drug absorption and on drug interactions due to membrane transporters Drug formulation development , GMP drug product stability and CMC documentation of injectable peptides Assessment of clinical trial applications and safety surveillance of active trials . Technologies :

membrane proteins;formulation;stability

Senior Lecturer in Biotechnology . . I am a passionate scientist , an entrepreneur and a mentor . I have developed an academic career that spans over 15 years , having taught in all levels primary to tertiary of education in Nigeria and mostly at the higher education level in UK . My research interest is largely in drug discovery with special interest in the development of novel anti diabetic agents from natural sources including plant species and amphibian skin secretions . My research output include several publications in reputable journals , an estate of patents and several awards such as the O Donovan Medal of the Irish Endocrine Society 2011 , Young Scientist Training Award of the European Association for the Study of Diabetes 2011 , Young Endocrinologists Trainee Award of The Society for Endocrinology 2012 , Best Poster Award at 2nd Peptide Workshop of the Irish Peptide Society and presentation to the UK 's House of Parliament . I have also generated substantial research funding . I am also committed to community outreach . This passion drove me to co found Bioscience Research Education and Advisory Centre details at www.breacnigeria.org ; a not for profit organization committed to the promotion of science education and research in Africa . Through this organization , I facilitate bioscience skill acquisition training workshops for students and scientists in Africa . I also established Cecejyde Lifesciences in August 2014 as the first Research Spin out company to facilitate research translation and capacity building in Africa . Over the past 15 years , I have occupied different positions through which I have developed capacities to mentor , support and provide pastoral care . I served previously as a Special Assistant to a Vice Chancellor , Acting Director of a research centre and Acting Head of a department , Leader of a music band , Executive Member of a national professional body and many more . . Technologies :

Senior Genomics Scientist . Developing methods for analyzing NGS data from CRISPR genome editing experiments including editing outcomes and off target effects . Analyzing NGS data from CRISPRi a screens and validated CRISPRi a screening libraries . Also analyzing sequencing data from ChIP Seq , RNA Seq , GUIDE Seq , AMP Seq and other sequencing experiments using novel pipelines , existing programs , and customized programs as needed . Developed a pipeline to automatically analyze editing outcomes in amplicon sequencing of hundreds of CRISPR edited samples simultaneously based on user created manifests . . . Technologies :